Quantitation by Gas Chromatography-Chemical lonization Mass Spectrometry of Cyclophosphamide, Phosphoramide Mustard, and Nornitrogen Mustard in the Plasma and Urine of Patients Receiving Cyclophosphamide Therapy1
نویسندگان
چکیده
Unambiguous and sensitive methods based on gas chromatography-chemical ionization mass spectrometry have been developed to quantitate Cyclophosphamide and two alkylating and cytotoxic metabolites, phosphoramide mustard and nornitrogen mustard. The levels of these materials have been determined in the plasma and urine of five patients receiving Cyclophosphamide, 60 or 75 mg/kg i.v. Peak plasma levels of phosphoramide mus tard of 50 to 100 nmoles/ml were found at 3 hr after Cyclophosphamide administration. Variable levels of nor nitrogen mustard were found in the plasma. This product may be arising in part from the decomposition of other metabolites during sample storage and preparation.
منابع مشابه
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